Categories : Tongue disorders Congenital disorders of digestive system. Mechanisms of Clinical Signs. Imperforate anus Rectovestibular fistula Persistent cloaca Rectal atresia. Macroglossia is uncommon, and usually occurs in children. A tongue that constantly protrudes from the mouth is vulnerable to drying out, ulceration, infection or even necrosis. Apparent macroglossia can also occur in Down syndrome. The ICD lists macroglossia under "other congenital malformations of the digestive system". No treatment may be required for mild cases or cases with minimal symptoms. Amyloidosis is an accumulation of insoluble proteins in tissues that impedes normal function.
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