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People often have drops in testosterone levels as they age, often called male menopause or "manopause," Samadi said. The same cholesterol plaques that can build up in the arteries surrounding the heart can also affect arteries that go through penile tissue. If a person has a large meal, such as a steak dinner, the fatty food may absorb some of the medication and reduce its efficiency, except for Cialis, which stays in the body for a long time, Samadi said. Follow her on Twitter LauraGeggel. In middle aged men, ED can signal risk of a heart attack, said Dr. A variety of lifestyle choices can affect the ability to achieve and maintain an erection, so preventing ED is possible in some cases. According to the NIH, the combination of ED pills with these other prescription medications can cause a sudden, dangerous drop in blood pressure. According to the Mayo Clinic, these include:.

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